Sildenafil Citrate is a revolutionary and time-tested component that is appreciated for its potent influence on several body functions promoting the desired effect. Belonging to a group of PDE-5 inhibitors, it is known as an erectile dysfunction treatment, while its action is influential enough to be used also as a pulmonary arterial hypertension. Due to the drastic and advantageous action produced, Sildenafil Citrate serves a basis for numerous effective and world-known pharmaceuticals, such as Viagra, Revatio and others.
Sildenafil and Its Impact on Erectile Function
Considering Sildenafil and mechanism of action, it is inevitable to mention that the medication affects the male body only. The treatment protects the cGMP (cyclic guanosine monophosphate) from degradation by PDE-5 (phosphodiesterase type 5) in the corpus cavernosum. Another chemical that participates in the process is nitric oxide that binds to receptors, called guanylate cyclase, and leads to vasodilation of smooth muscles of the arteries. Such an influence on the arteries stimulates a boosted blood flow into penile tissues, causing an erection.
Irrespective of Sildenafil action and its beneficial impact on the organism, the medication will not work without previous sexual stimulation. The usual stimulation activates the cGMP and NO systems that help to achieve a stiff and hard erection.
Sildenafil Citrate as Pulmonary Arterial Hypertension Treatment
Another question that is often asked: how does Sildenafil citrate work for pulmonary hypertension? The answer is rather simple. While the mechanism of action remains almost the same, the ingredient stimulates other improvements. Sildenafil is classified as a selective phosphodiesterase type 5 inhibitor. The PDE-5 is present all throughout the body, though it is highly concentrated in the lungs. The process of PDE-5 inhibition promotes vasodilatory influence of the Nitric Oxide in pulmonary hypertension. Sildenafil Citrate warns cyclic guanosine monophosphate degradation, thus, enhancing the relaxation of smooth muscles and increasing the blood flow.
Sildenafil Side Effects and Other Complications
Despite the powerful and undeniably beneficial influence of Sildenafil Citrate on the organism, it should be administered in proper doses and in accordance with other safety issues. The slightest misuse or overuse of the medication may trigger a range of undesirable reactions and abnormalities.
To begin with, it is important to mention common Sildenafil side effects that are a usual reaction to new ingredients in the body. Vision impairments, stomach disorders, headache, flushing, dizziness, stuffy or runny nose and other symptoms may appear after the medication intake. However, these reactions are supposed to disappear soon. Call your healthcare provider in case the conditions aggravate and launch the development of more serious side effects, such as:
- Uneven heartbeats;
- Hearing problems;
- Allergic reactions;
- Symptoms of heart attack and others.